Effect of Nephropathy Prescription I on the Expression of Angptl3 and Podocyte-Associated Protein in Mice with Adriamycin-Induced Nephropathy

Objective. This study aimed to investigate the effects of Nephropathy Prescription I on expression angptl3, nephrin, and podocin, in addition its protective podocytes mice with adriamycin-induced nephropathy. Methods. BALB/c were randomly divided into control (C), adriamycin (Model or M), + (M Z), prednisone acetate S), groups Z S). All except those C group experimental treated a single tail vein injection adriamycin. The urine albumin-creatinine ratio was measured before model establishment 7th day, 14th 21st 28th day doxorubicin injection. sacrificed 29th day. Blood samples collected observe biochemical indicators serum. morphological structure podocyte ultrastructure kidney observed using light electron microscopy, respectively. podocin at mRNA protein levels detected by real-time PCR western blotting, Results. Following modeling adriamycin, albuminuria first week, urinary protein/creatinine increased maximally fourth week M ( P < 0.05 ). In contrast, significantly decreased id="M2"> ) third Z) compared that group. Similarly, this S) throughout experiment. Compared group, serum albumin content nephrin id="M3"> ), whereas blood lipid level angptl3 id="M4"> Glomerular foot process fusion microscopy. all intervention groups, id="M5"> id="M6"> alleviated glomerular injury particularly Conclusion. can alleviate albuminuria, increase levels, lower reduce processes may function reducing Angptl3 increasing expression.